Alzheimer's disease (AD) is a late-onset disease that usually occurs in individuals over the age of 65. Thanks to advances in modern healthcare, people will now live longer, therefore leading to an increase in the number of people with AD. Alzheimer's disease continually progresses with age leading to cognitive impairment and ultimately death. It is currently the sixth leading cause of death, with no current prevention or treatment methods. Past research with theanine has provided some promise. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay Theanine is a biomolecule found primarily in tea-producing plants. Previous studies have supported that it can potentially be used as a prophylaxis or treatment method for individuals suffering from AD. It has been found that excessive NMDA receptor stimulation can lead to an increase in amyloid beta peptides in certain regions of the brain, which is characteristic of the disease. The increased receptor activation also caused high toxic release of glutamate, which signaled neuronal cell apoptosis. Theanine has been shown to block the NMDA receptor, which ends up suppressing apoptosis and reducing the amount of amyloid beta peptides formed in AD. In this article I will analyze the study conducted by Kazuki et al. and how they used theanine as a treatment for patients with neurodegenerative diseases. The purpose of their study was to see the treatment effects that green tea extracts (theanine and catechins) had on elderly individuals with cognitive impairments. To obtain the appropriate sample Kazuki et al recruited 12 participants from a nursing home. Two of the participants were male and ten were male. This may have led to a confounding factor because women tend to have higher cases of AD in later life. The average age of the participants was 88 years. Each participant had early Alzheimer's or another type of neurodegenerative disease. There was also a set of inclusion and exclusion criteria. Some of the inclusion criteria were that participants had to be over 65 years of age and had to be able to consume green tea extract powder orally. The numerous inclusion and exclusion criteria mean that the study has lower external validity. Therefore, the WSR model becomes weaker because individuals who do not fit the inclusion criteria will not be considered. One of the patients was taking medications prescribed for dementia. This could have led to a confounding factor and provided weaker evidence in the EBM perspective. Participants consumed powdered green tea for three months. Participants were administered a mini-mental status examination (MMSE) to assess the level of their cognitive deficits. The lower the score, the greater their cognitive impairment. The exam had five components. Additionally, data on the patients' blood pressure, serum lipid levels, and blood glucose levels were collected. This was done because atherosclerosis has been shown to increase the likelihood of AD. Atherosclerosis is caused by high blood pressure. Then, they checked to see if the extract would have any effect on lowering blood pressure. This process took a more holistic approach because it related multiple diagnoses together. All test scores were taken at the beginning and after the three-month period. Total MMSE scores improved significantly by the end of the study. Please note: this is just a sample..4373