Staphylococcus aureus (S. aureus) is considered both a Gram-positive bacterium and a pathogen and is capable of causing many human diseases (Gordon & Lowy, 2008; Deurenberg, Vink , Kalenic, Friedrich, Bruggeman & Stobberingh, 2006). S. aureus is one of the most common causes of skin and soft tissue infections (SSTIs) (Hansra & Shinkai, 2011). It can also cause postoperative wound site infections, necrotizing pneumonia, and bacteremia (Deurenberg et al., 2006). Methicillin resistance is one of the main subtypes of this bacterium. It is therefore called methicillin-resistant Staphylococcus aureus (MRSA) (Hansra & Shinkai, 2011). MRSA is generally considered a nosocomial infection (Witte, 2009), meaning it originates from the hospital environment. The mecA gene determines methicillin resistance (Gordon & Lowy, 2008). mecA encodes the 78 kDa penicillin binding protein (PBP) 2a ( Deurenberg et al., 2006 ). β-Lactam antibiotics normally bind to PBPs in the cell wall (Deurengerg et al., 2006). This causes disruption of the synthesis of the peptidoglycan layer and ultimately the death of the bacterium (Deurenberg et al., 2006). Since β-lactam cannot bind to PBP2a, the synthesis of the cell wall and peptidoglycan layer can continue (Deurenberg et al., 2006) and the bacterium does not die. This article focuses on a client who developed MRSA while hospitalized. The purpose of this article is to explain signs and symptoms, risk factors, diagnostic and laboratory tests used, dietary and nutritional implications, and the pharmacological treatment of MRSA. Signs and Symptoms MRSA is most commonly found in the anterior nares and one-quarter to one-third of the population carries MRSA at any time (Miller & Die... half of paper...), 263-272 . doi:10.1111/j.1529-8019.2011.01402.xLehne, R. A. (2013). Pharmacology for nursing (8th ed.). Saunders.McCance, K., Huether, S., Brashers, V., & Rote, N. (2010). Pathophysiology: The Biological Basis of Disease in Adults and Children (6th ed.). Mosby Inc. Miller, L. G., & Diep, B. (2008). Colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. Clinical Infectious Diseases, 46(5), 752-760. doi:10.1086/526773Newland, J. G., & Kearns, G. L. (2008). Treatment strategies for methicillin-resistant Staphylococcus aureus infections in pediatrics. Pediatric Drugs, 10(6), 367-378. Witte, WW (2009). Community-acquired methicillin-resistant Staphylococcus aureus: what should we know? Clinical microbiology and infection, 1517-25. doi:10.1111/j.1469-0691.2009.03097.x