IntroductionThe adult central nervous system (CNS) is composed of cells from two distinct lineages: neurons and glial cells. Neurons are the basic building blocks of the central nervous system responsible for communicating information via electrochemical mechanisms. Glial cells (astrocytes and oligodendrocytes) surround the neurons; provide them with support and isolation. “No new neurons after birth” or “the adult human brain cannot regenerate” has been the dogma of neuroscience in the last century (1). Recently, this principle has been called into question by the discovery of the NPC in the nervous system of both embryonic and adult mammals ( 1 , 2 ). This has brought new insight into neuroscientific research that the more “stubborn” nervous system-tissue may have regenerative supremacy. Likewise, these highly plastic cells are not only present in the main neurogenic regions of the adult (hippocampus and subventricular zone), but also in non-neurogenic regions, including the spinal cord (3). Several studies had identified NPCs based on their behavior after isolation. These cells can be cultured as adherent cells that consist...